|
KMID : 0931320100100010014
|
|
대한상부위장관.헬리코박터학회지
2010 Volume.10 No. 1 p.14 ~ p.20
|
|
|
Impact of Clarithromycin Resistance on the Outcome of Standard Triple Helicobacter pylori Eradication Therapy
|
|
Lee Jung-Hyun
Sung In-Kyung
Kim Jeong-Hwan
Lee Sun-Young
Hong Sung-Noh
Park Hyung-Seok
Shim Chan-Sup
Jin Choon-Jo
Han Hye-Seung
Kim Kyun-Hwan
|
|
|
Abstract
|
|
|
Background/Aims: Clarithromycin resistance in Helicobacter pylori is a major cause of the failure of eradication therapy. The object of this study was to determine the impact on impact of clarithromycin resistance on the outcome of standard triple Helicobacter pylori eradication therapy.
Methods: From August 2005 to June 2009, The total of 798 patients with H. pylori infection and treated with standard H. pylori triple eradication therapy (proton pump inhibitor, amoxicillin, clarithromycin) were analyzed. The Pyrosequencing assay was carried out to detect H. pylori 23S rRNA mutations.
Results: The eradication rates with standard triple therapy was 84.5% (673/798). The rates of 23S rRNA point mutation were 44.7% for the failed standard triple therapy group, which was higher than the 5.3% for the successfully eradicated control group (p=0.001).
Conclusions: The clarithromycin resistance significantly affected the standard triple H. pylori eradication therapy. Therefore, the detection of clarithromycin resistance mutation in H. pylori by pyrosequencing before H. pylori eradication therapy may be helpful to select the best regimen to get successful H. pylori eradication. (The Korean Journal of Helicobacter and Upper Gastrointestinal Research 2010;10:14-20)
|
|
|
KEYWORD
|
|
|
Helicobacter pylori, Standard triple therapy, Clarithromycin resistance, 23S rRNA point mutation, Pyrosequencing assay
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|